Pharmaceutical Industry Applications for Dynamic Vapor Sorption
In the pharmaceutical industry, materials get into contact with water in many different ways, for example during manufacturing steps such as crystallization processes, spray drying or wet granulation. Also, during storage and transport, pharmaceutical raw materials or final products are typically exposed to an atmosphere containing water vapor, causing interactions between solids and water. In multi-component formulations, water may also migrate between moist and dry ingredients. With regard to the compaction behavior during tabletting, a certain moisture content is required to obtain satisfactory products. In general, however, the exposure to moisture causes undesirable product changes. Therefore, it is of utmost importance for the development of new drugs to have comprehensive and detailed information on water-solid interactions and the influence of moisture on the physicochemical properties of Active Pharmaceutical Ingredients (APIs) and excipients.